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Document 2532
DOCN M94A2532
TI Slower heterosexual spread of HIV-2 compared with HIV-1.
DT 9412
AU Kanki PJ; Mboup S; Travers K; Marlink R; Siby T; Essex M; Harvard School
of Public Health, Boston, MA.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):282 (abstract no. PC0050). Unique
Identifier : AIDSLINE ICA10/94370043
AB OBJECTIVE: Based on similar virologic properties, human immunodeficiency
virus type 2 (HIV-2) has been considered as infectious and capable of
inducing AIDS as HIV-1. It is therefore important to understand the
transmission properties of HIV-2 in order to more accurately predict
this virus' contribution to the growing AIDS pandemic. The measurement
of HIV incidence is critical to our understanding the dynamics of both
HIV-1 and HIV-2 spread in populations at-risk and future design of
vaccine efficacy trials. METHODS: Since 1985, we have prospectively
studied 1452 registered female prostitutes in Dakar, Senegal, with
sequential evaluation of their antibody status to HIV-1 and HIV-2.
Incidence rates of HIV seroconversion were calculated annually and over
the study period. Poisson regression models were used to describe
temporal changes in HIV incidence and demographic variables associated
with seroconversion. RESULTS: From 1985 to 1993, the overall incidence
of HIV-2 was 1.11/100 person-years (pyo) (95% CI 0.83-1.48), and also
1.11/100 pyo for HIV-1 (95% CI 0.83-1.48). In this limited analysis,
risk-factors for infection differed between HIV-1 and HIV-2. Over the
8-year period, the annual incidence of HIV-2 remained stable, despite
higher HIV-2 prevalence. Over the 8 year period, the annual incidence of
HIV-1 dramatically increased, with a 1.4 fold increased risk per year
and thus a 12-fold increase over the study period. CONCLUSION: In our
study population, the heterosexual spread of HIV-2 is significantly
slower than that of HIV-1, which strongly suggests differences in the
infectivity potential of these two related immunodeficiency viruses.
DE Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/MICROBIOLOGY/
*TRANSMISSION Female Human *HIV-1 *HIV-2 Incidence Prospective
Studies Prostitution Risk Factors Senegal/EPIDEMIOLOGY *Sex Behavior
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).